San Diego, Calif., Jan. 28, 2019 -- A team of researchers led by the University of California San Diego has identified a genetic pathway that causes some individuals to develop an abnormal heart rhythm, or arrhythmia, after experiencing a heart attack. They have also identified a drug candidate that can block this pathway.
The team reported their findings in a study published Jan. 28 in Nature Biomedical Engineering.
“We now know one reason why a significant fraction of the public could develop secondary complications post heart attack, like an arrhythmia,” said Adam Engler, a bioengineering professor at the UC San Diego Jacobs School of Engineering. “We have identified the adverse reactions that cause this comorbidity in certain patients and can begin to develop drugs to treat and prevent it.”
This pathway from heart attack to arrhythmia is triggered by genetic mutations located in a region of the genome called the 9p21 locus. These mutations are present in about 23 percent of the population.
“Past studies have suggested that mutations in the 9p21 locus could be linked to these cardiovascular diseases, but there was no understanding of why and how. Now we have specific answers to these questions,” said first author Aditya Kumar, a bioengineering PhD student in Engler’s lab.
Engler, Kumar and colleagues discovered that when a heart attack hits, the mutations activate a key player in the pathway—a signaling protein called JNK. Normal heart cells can keep JNK in check after a heart attack. But in cells with the mutations, JNK sends signals to downstream targets that ultimately break electrical connections between heart cells and cause them to beat out of sync.
Researchers also showed they could reverse and prevent this damage by blocking JNK. They used a molecule called SP600125. It’s a known JNK inhibitor, but according to Engler its derivatives have not been tested clinically for cardiac conditions related to 9p21 as they may have off-target effects.
“In the future, we envision that cardiac patients could have their genomes sequenced and if they have the 9p21 mutations, they could be given a drug based on this inhibitor so they are better off in the event of a heart attack and won’t develop arrhythmia,” said Engler.
Abnormal heart rhythm, arrhythmia, after experiencing a heart attack