Faculty Profiles
Integrated Systems Neuroengineering
Neuromorphic engineering, computational and systems neuroscience, neuron-silicon and brain-machine interfaces, learning and intelligent systems.
Lab Location(s) & Extension(s):
PFBH 304-x49422
Vascular Molecular Bioengineering
Molecular mechanisms by which mechanical forces modulates signal transduction and gene expression.
Lab Location(s) & Extension(s):
SERF 286-x46167 | PFBH 388-x45251
KAREN L. CHRISTMAN
kchristm@ucsd.edu
PFBH 202-x27863
Biomaterials and Regenerative Medicine
Dr. Christman's research interests and expertise focus on the regeneration of injured and diseased cardiovascular tissues in vivo by making use of polymer chemistry and nanotechnology methods to develop novel biomaterials for tissue implantation and cell delivery. Dr. Christman's doctoral research was the first to recognize that appropriate biopolymers alone can affect post-myocardial infarction remodeling, both highlighting the importance of the physical and chemical properties of polymer scaffolds on tissue healing and showing the need for non-cellular controls in assessing the effects of cell-based therapies for myocardial infarction in vivo.
Lab Location(s) & Extension(s):
PFBH 202-x27863
ADAM J ENGLER
Stem Cell Biology and Bioengineering Laboratory
Research Areas:
1) Extracellular matrix regulation of embryonic and mesenchymal stem cell differentiation
2) Developmental biology and mechanics of precardiac mesoderm
3) Cell adhesion to 3-dimensional fibronectin matrix
Lab Location(s) & Extension(s):
PFBH 344-x60332
YUAN-CHENG FUNG
yufung@ucsd.edu
PFBH 133-x44278
Tissue Remodeling Mechanics
Stress-growth law of blood vessels. Inventing new techniques and developing new experiments to determine the zero-stress state and the constitutive equations of blood vessel components such as collagen, elastin, and smooth muscle; lumped layers such as the endothelium, the media, and the adventitia; and the vessel as a whole. Morphometry of systemic and pulmonary blood vessels in health and disease. Continuum mechanics in pulmonary physiology; theory to integrate morphology, mechanical properties, rheology, thermal environment, and boundary conditions into a pressure-flow relationship.
Lab Location(s) & Extension(s):
PFBH 351
DAVID A. GOUGH
PH.D., UNIV OF UTAH
dgough@ucsd.edu
PFBH 484-x23446
Biosensors
Development and application of biochemical-specific senors.
Lab Location(s) & Extension(s):
PFBH 486-x41130
JEFF M HASTY
PH.D., THE GEORGIA INSTITUTE OF TECHNOLOGY
jmhasty@ucsd.edu
PFBH 404-x23442
Biodynamics
Utilization of nonlinear dynamics and statistical physics in the design, construction and analysis of gene regulatory networks.
Lab Location(s) &Extension(s):
PFBH 406-x23856
Nanotechnology
Development of high performance bioanalytical techniques and technologies for genomic, proteomic and phamacogenomic applications.
Lab Location(s) & Extension(s):
PFBH 406
XIAOHUA HUANG
Genomics and Systems Biotechnology
Development of future-generation genome sequencing technologies for biomedical research and personalized medicine; Development of microfluidic devices for high-throughput single cell proteomic and genomic analyses; Protein engineering; Micro- and nano-fabrication; Chemo-mechanical nanosensors and single molecule fluorescence imaging.
Lab Location(s) & Extension(s):
PFBH 487-x22155
TREY IDEKER
tideker@ucsd.edu
PFBH 204-x24558
Laboratory for Integrative Network Biology
Evolutionary comparison of protein interaction networks; Modeling the gene regulatory and protein signaling networks responding to DNA damage.
Lab Location(s) & Extension(s):
PFBH 206-x20418
Microhemodynamics
Development of new blood substitute using modified hemoglobin. Mechanism of microcirculatory regulation.
Lab Location(s) & Extension(s):
PFBH 253-x42315
Cardiac Mechanics
In-vivo, in vitro and computational models to investigate the relationships between the cellular and extracellular structure of cardiac muscle and electrical and mechanical function of the normal and diseased heart. Tissue engineering for cardiac regeneration. Systems biology approaches to cardiac genotype-phenotype relationships.
Lab Location(s) & Extension(s):
PFBH 242-x45796
MELISSA KURTIS MICOU
mmicou@ucsd.edu
PFBH 229-x21087
Lab Location(s) & Extension(s):
PFBH 229-x21087
Systems Biology and Genetic Circuits
Reconstruction of genome scale networks (metabolic, regulatory and signaling). Mathematical assessment of their properties and experimental determination of their functions. Systems Biology.
Lab Location(s) & Extension(s):
PFBH 412-x20028 | PFBH 409-x23076 | PFBH 413-x21144 | PFBH 414-x21168 | PFBH 417-x23180 | PFBH 428-x48758
Cartilage Tissue Engineering
Tissue engineering for functional restoration of cartilage and diarthrodial joints. Multiscale mechanobiology of cartilage in growth, aging, and osteoarthritis. Lubrication biomechanics of articular cartilage. Biomechanical and biochemical regulation of chondrocyte and matrix metabolism.
Lab Location(s) & Extension(s):
PFBH 314-x45682
Microcirculation
Use of experimental and mathematical tools of bioengineering to identify the mechanisms for important cardiovascular diseases and microcircualtion. Molecular analysis of the auto-digestion hypothesis for organ failure.
Lab Location(s) & Extension(s):
PFBH 286-x42714
GABRIEL A SILVA
M.SC. U. OF TORONTO, PH.D. U. OF ILLINOIS, CHICAGO
gsilva@ucsd.edu
JRC 204-x24591 | PFBH 386-x24591
Neural Engineering
Systems neuroscience and applied nanotechnology for investigating intercellular signaling in the central nervous system under physiologically normal conditions and following disease integrated across spatial scales, from individual cells to large neural cell networks.
Lab Location(s) & Extension(s):
204 Jacobs Retina Center-x24591
Bioinformatics and Systems Biology
Bioinformatics and Systems Biology. Networks and phenotypes for mammalian biology.
Lab Location(s) & Extension(s):
EBU1 5501-x23228
Molecular Bioengineering
Molecular structure, genomic organization and control of gene expression of membrane skeletal proteins in relation to mechanical properties of cells and tissues. Targeted disruption of genes and disease phenotypes. Intrrinsic helix and external ruler mechanisms for actin protofilament length control. 3-D model of a juctional complex where spectrin and actin meet. The topology and 3-D dynamics of the membrane skeleton. Biomechanics of DNA and nucleosomes. Mechanical and immunological bases of cell death in human.
Lab Location(s) & Extension(s):
PFBH 335-x20005
SHYNI VARGHESE
svarghese@ucsd.edu
PFBH 124-x27920
Biomaterials and Stem Cell Engineering
Dr. Vargheses interests and expertise lie in the application of novel and rational biomaterials design and synthesis to the repair and regeneration of injured and diseased tissues, especially for developing stem cell-based therapies for musculoskeletal defects. Her interests lie at the interface between stem cell biology, cell-matrix interactions, and molecularly engineered biopolymers for regulating stem cell fate and commitment, and regenerative medicine.
Lab Location(s) & Extension(s):
PFBH 124-x27920
Heart Failure and Public Policy
Translating benefits to patients more efficiently, activities leading to policies and incentives that reduce the number of years from conception of a new medical innovation until it reaches general clinical use and commercialization.
Lab Location(s) & Extension(s):
PFBH-x22788
KUN ZHANG
k4zhang@ucsd.edu
PFBH 404-x27876
Integrative Genomics
With his diverse interdisciplinary training in biophysics, neuroscience, genomics and human genetics, Dr. Zhangs research has focused on the development and application of new genome technologies, with an emphasis now on stem cell research and personalized medicine.
Lab Location(s) & Extension(s):
PFBH 404-x27876
Department of Bioengineering | 9500 Gilman Drive, La Jolla, California 92093-0412
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