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UC San Diego clinician-engineer teams selected as 2018 Galvanizing Engineering in Medicine awardees

September 6, 2018

UC San Diego clinician-engineer teams selected as 2018 Galvanizing Engineering in Medicine awardees

Four clinician-engineer teams from UC San Diego have been selected to receive the 2018 Galvanizing Engineering in Medicine (GEM) awards. GEM, an initiative of UC San Diego Altman Clinical and Translational Research Institute (ACTRI) and UC San Diego Institute of Engineering in Medicine (IEM), brings engineers and clinicians together to develop innovative technologies that can be applied to solving challenging problems in medical care. This year’s projects address challenges in the areas of urology, telerobotic surgery, oncology, and spinal cord injuries. Full Story


Scientists discover a destructive mechanism that blocks the brain from knowing when to stop eating

August 22, 2018

Scientists discover a destructive mechanism that blocks the brain from knowing when to stop eating

An international team of researchers has uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity, called leptin resistance.They found that mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This blocks leptin from binding to its receptors. This in turn keeps the neurons from signaling that your stomach is full and you should stop eating. This is the first time that a destructive molecular mechanism has been observed and described. Full Story


Bioengineers receive $12M grant from NIH to further research on building blocks of human metabolism

August 17, 2018

Bioengineers receive $12M grant from NIH to further research on building blocks of human metabolism

The University of California San Diego has received a $12 million, four-year grant from the National Institutes of Health to expand the Metabolomics Workbench, a searchable, interactive repository of data for all research in the field of metabolomics—the study of the small molecules called metabolites  that are found within cells and biological systems. The Metabolomics Workbench project, led by bioengineering professor Shankar Subramaniam at the Jacobs School of Engineering at UC San Diego, launched in 2012 with a $6 million grant from the NIH. This new infusion of funds will allow Subramaniam and colleagues to add a wide range of clinical data to the Workbench and take the project into the clinic itself. This in turn will allow researchers and physicians to develop better tools to diagnose diseases through metabolite markers in blood. Full Story