NHLBI Training Grant Program

Training in Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and Disease is a novel program in bioengineering predoctoral training in cardiopulmonary science and technology at UC San Diego. It takes advantage of UC San Diego’s leadership as a top-ranked bioengineering doctoral program focused on basic research and technology development together with world-leading NHLBI-supported basic and clinical science in cardiovascular and cardiopulmonary disease and healthcare.

In the past five years, Engineering at UC San Diego has recruited seven diverse new faculty with expertise in cardiovascular imaging and biophotonics, pulmonary hypertension, cardiovascular biomechanics, neurovascular engineering, biomaterials, heart valve disease, congenital heart disease, and sex differences in cardiovascular disease, including several with cross-disciplinary appointments.

This new program will be the only graduate program on campus to provide bioengineering predoctoral students with interdisciplinary co-mentored training to apply four key technology themes to basic and translational problems in cardiac, vascular, blood and lung health.

ABOUT THE PROGRAM 

FOCUS & AIM

 

Train the next-generation interdisciplinary research workforce skilled at developing and using engineering technologies and analysis for basic and translational research that improves understanding, prevention and treatment of cardiovascular and cardiopulmonary diseases.

Train predoctoral bioengineering students in applying quantitative and integrative interdisciplinary approaches to basic and translational research in cardiopulmonary, vascular, blood and sleep pathophysiology and developing novel technologies for the diagnosis, treatment and clinical management of cardiovascular and cardiopulmonary diseases.

 

TRAINEE SELECTION

 

Trainees will be selected from predoctoral candidates admitted to our highly ranked and competitive Bioengineering doctoral program.

Selected trainees will take courses on cardiovascular biology and engineering technologies specific to the proposed program, have a clinical immersion experience, and conduct laboratory research in cardiovascular science with interdisciplinary co-mentors.

Students accepted into the training program may be eligible to receive support through the NIH National Heart, Lung, and Blood Institute (NHLBI) T32 Graduate Research Training Grant which was officially awarded by the NIH in March, 2022. Training grant fellowships often have the following citizenship information requirements: 

Kirschstein-NRSA trainees and institutional career development scholars must be U.S. citizens, non-citizen nationals, or permanent residents of the United States. Individuals on temporary or student visas are not eligible. Trainees or scholars in these programs who are permanent residents of the U.S. must submit a notary’s signed statement with this appointment form certifying that they have (1) A Permanent Resident Card (USCIS Form I - 551), or (2) other legal verification of such status.

 

PARTICIPATING DEPARTMENTS

 

Bioengineering

Biological Sciences

Halıcıoğlu Data Science Institute 

La Jolla Institute for Allergy and Immunology

Mechanical and Aerospace Engineering 

School of Medicine 

Skaggs School of Pharmacy and Pharmaceutical Sciences 

 

PROGRAM FACULTY

BIOENGINEERING

Brian Aguado, PhD is an Assistant Professor who joined UCSD in 2021. His research develops precision biomaterials for studying patient-specific biology as a function of sex, age, or ancestry. He is currently focused on exploring sex differences in cardiovascular diseases (aortic valve stenosis, cardiac fibrosis) at multiple length scales using precision biomaterial tools. Dr. Aguado is pursuing collaboration with Drs. Christman, Engler, Fraley, Valdez-Jasso, Kwon, King, and Reeves.

Pedro Cabrales, PhD analyzes cardiovascular transport and regulation using engineering principles and methods. Recent trainees worked on assessing cardiac function during oxidative stress and blood substitutes, co-mentored with other training faculty, including Drs. Kwon, Christman, Contijoch and Haddad. Trainees develop new techniques to understand in-vivo transport, and quantify organ and tissue function in anemia, hemorrhagic shock, brain injury, polycythemia, malaria and sickle cell disease.

Karen Christman, PhD  develops injectable biomaterials for tissue engineering and regenerative medicine as minimally invasive therapies for myocardial infarction, congenital heart defects, peripheral artery disease and Covid. She collaborates with many training faculty, including Drs. Engler, Evans, Kwon, Contijoch, Sheikh, and Reeves and has co-mentored many trainees. She will serve as a program co-director. 

Francisco Contijoch, PhD (Bioengineering and Radiology) develops imaging techniques for cardiovascular assessment. Trainees develop advanced MR and CT analysis techniques for assessing right ventricular and pulmonary vascular function in patients with pulmonary hypertension, congenital heart disease, or mechanical circulatory support.  He co-mentors trainees with Drs. Christman, Malhotra, and McVeigh.

Adam Engler, PhD works on mechanobiology in heart disease and cancer. His trainees use novel biomaterials and tissue engineering to study how physical and chemical properties of the extracellular niche influence or misregulate cell function and modify genetic mechanisms of disease. He has co-mentored trainees with Drs. Chi, Fraley, Ross, McCulloch, Christman, Hsaio, Kwon, and Mali. 

Stephanie Fraley, PhD studies the systems biology of extracellular matrix regulation of epithelial-to-endothelial transition and collective cell migration. The ability of adult differentiated cells to regain plasticity and transdifferentiate down distinct lineages is leading to new regenerative strategies. She collaborates with Drs. Engler, McCulloch & Valdez-Jasso and is department Diversity Chair.

Kevin King, MD, PhD (Bioengineering and Medicine-Cardiovascular Medicine) is a clinical cardiologist and bioengineer studying inflammation and tissue remodeling in myocardial infarction. His trainees use single cell transcriptomics to understand how the immune system responds to injury and influences repair. They also develop tools for in-home monitoring of heart failure patients. He collaborates with Drs. Brown, Christman, and Engler.

Ester Kwon, PhD works on nanotechnology and bioinspired materials. Her trainees develop new biomaterial technologies for treating traumatic brain injury by discovering new ways to interact with and repair the damaged blood vessels in the brain. She collaborates with Drs. Christman, Engler, Mali and Contijoch. 

Klaus Ley, MD (Bioengineering and La Jolla Institute for Allergy and Immunology) studies the adaptive immune response in atherosclerosis in humans and mouse models. His trainees use advanced imaging and in-vivo models of inflammation as a defense reaction to tissue injury. They are also testing a vaccine against atherosclerosis that is effective in mice. He collaborates with Dr. Mali.  

Prashant Mali, PhD (Bioengineering) works on understanding cell fate specification during early development and disease modeling with vascularized organoids. His trainees develop new technologies for cell engineering and genome editing and use systems biology to enable high resolution, high throughput deciphering of the genetic code in human stem cells. He collaborates with Drs. Christman, Fraley, Wang, Engler and Ley.

Andrew McCulloch, PhD (Bioengineering and Medicine) uses experimental and computational modeling to investigate cardiac biomechanics, electrophysiology and regulatory mechanisms. Recent trainees worked on molecular modeling of myofilament dynamics, network analysis of myocyte mechanosignaling and patient specific-modeling of heart failure, atrial fibrillation and congenital heart diseases, co-mentored by many other training faculty including Drs. Brown, Evans, Chen, Sheikh, Ross, Engler and Haddad.

Elliot McVeigh, PhD (Bioengineering, Medicine and Radiology) develops novel cardiovascular imaging techniques using MRI and CT. His trainees develop scanning and image analysis techniques for individualized analysis of patients by applying advanced engineering concepts to address unmet needs.  He collaborates with Drs. Hsaio, Contijoch, Reeves and Kahn.

Geert Schmid-Schoenbein, PhD, PhD studies microvascular mechanics and physiology in inflammatory disease. His trainees develop new molecular technologies for detection of cardiovascular organ failure in hypertension, heart failure and hemorrhagic shock, and for preventing it by targeting proteolytic degradation by digestive enzymes. He collaborates with Drs. Christman and McVeigh.

Lingyan Shi, PhD develops novel optical imaging techniques to visualize structural dynamics and metabolism of the vascular system in vivo. Her trainees develop multimodal optical imaging of vasculature dynamics and their relationship to neural activity-regulated signaling in vascular endothelial cells. She joined the Bioengineering faculty as Assistant Professor in 2019 and is collaborating with Dr. Wang, Cabrales and Zhong.

Daniela Valdez-Jasso, PhD works on soft-tissue biomechanics, mechanobiology and multi-scale modeling of right ventricular and pulmonary arterial adaptations to pulmonary arterial hypertension. She incorporates organ-, tissue-, and cellular-level experimental findings into mechanistic mathematical models. Her trainees use in-vitro, in-vivo and computational models and are co-mentored with Drs. McCulloch and Malhotra. She will be the T32 diversity coordinator. 

Yingxiao Wang, PhD works on molecular engineering for cellular imaging and reprogramming. His trainees design and use molecular FRET biosensors for visualizing signaling dynamics and microdomains in live cardiovascular cells. Immune cells are engineered cells to control cellular function. He is collaborating with Drs. Engler and Fraley.

Kun Zhang, PhD develops novel genomics and imaging approaches and applications to stem cells and human adult tissues. He is chair of Bioengineering and leads an NIH HuBMAP U54 center for building 3D single-cell maps for human lungs and other organs. He collaborates with Drs. Mali & Chi.

Sheng Zhong, PhD  studies the relationship between gene regulatory networks and cellular behavior. The primary goal of his trainees is to develop new technologies to reveal RNA-participating molecular networks, including the RNA-RNA interactome. He collaborates with Dr. Chen.

BIOLOGICAL SCIENCES

Sonya Neal, PhD works on understanding protein quality control pathways, especially those that detect and destroy toxic misfolded proteins. This allows her trainees to define the mechanisms that protect the proteome in health and disease, and devise methods to harness cellular quality control to modify the proteome in the lab and clinic. She is a faculty member of the NHLBI FOCUS program with Drs. Contijoch and Valdez-Jasso and runs a program to promote success in URM trainees.

MECHANICAL AND AEROSPACE ENGINEERING

Stephanie Lindsey, PhD (Mechanical and Aerospace Engineering and Bioengineering) is a new Assistant Professor who joined the MAE faculty in 2021. She studies how hemodynamic forces affect cardiovascular development. Her trainees use experimental and computational models to discriminate effects of hemodynamic versus genetic alterations in aberrant cardiogenesis and congenital heart defects. 

MEDICINE

Sylvia Evans, PhD (Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences) studies cardiac development and its application to heart disease in mouse models. Her trainees study pathways regulating how mesodermal precursors become committed to cardiac progenitors, specified into lineages, and assemble the heart. She co-mentors trainees with Drs. Chen, Brown, McCulloch and Christman.

Emma Farley, PhD (Medicine and Biological Sciences) studies how enhancers encode the patterns of gene expression required for successful cardiovascular development and the mutations within enhancers that lead to developmental defects and evolutionary adaptations. Her trainees’ research is highly multidisciplinary. She is pursuing collaboration with Dr. Christman and Evans.   

Mark Ginsberg, MD works on vascular biology and hemostasis-thrombosis, signal transduction, gene regulation, hematopoiesis, angiogenesis, and the molecular and cell biology of blood and vessel walls. He also directs the UC San Diego Physician-Scientist Training Pathway and has collaborated with Dr. Ley.

Atul Malhotra, MD conducts research to understand why patients with respiratory diseases such as obstructive sleep apnea, chronic obstructive pulmonary disease and Covid-19 have cardiovascular complications. His trainees focus on the pathogenesis of sleep apnea and its complications. He has a successful track record of mentoring and collaborates with Drs. Contijoch and Valdez-Jasso.

MEDICINE-CARDIOVASCULAR MEDICINE

Ju Chen, PhD is a leading expert in molecular cardiology and genetically engineered mouse models of cardiac and skeletal myopathies. He has co-mentored trainees with Drs. Brown, Chi, Sheikh, McCulloch, Ross and Zhong.

Neil Chi, MD focuses on discovering the fundamental basis of how diverse cardiovascular lineages are created and assembled to form and repair the functioning heart and cardiovascular system. He co-mentors trainees with Drs. Chen, Engler, McCulloch and Evans on cardiovascular stem cells, genetics and systems biology.

Andrew Kahn, MD works on image-based analysis of cardiac hemodynamics. His research focuses on using clinical cardiac CT, MRI, and echocardiography imaging to measure and analyze intra-cardiac flows and create patient-specific computational fluid dynamics simulations. He has collaborated with Drs. Contijoch, McVeigh, and Reeves. 

Ryan Reeves, MD  is an interventional cardiovascular clinician and researcher. His interests include coronary physiology, acute and chronic heart failure, post-heart transplantation complications, and therapies for coronary and structural heart disease. He co-mentors Bioengineering trainees with Dr. Christmanand Contijoch.

Robert Ross, MD works on understanding the mechanisms of cardiac hypertrophy and heart failure, with a focus on cell-matrix and cell-cell interactions in the myocardium. He co-mentors Bioengineering predoctoral trainees with Drs. McCulloch, Engler, Wang, Chen, and Brown.

Farah Sheikh, PhD investigates mechanisms and therapeutics for arrhythmogenic right ventricular cardiomyopathy. Her trainees are focused on understanding pathways driving biomechanical stress responses in cardiac muscle and on mutations in desmosomes associated with ARVC. She has co-mentored bioengineering predoctoral trainees with Drs. Chrstiman, Evans and McCulloch.

John Shyy, PhD  investigates molecular mechanisms by which fluid shear stress and pro-inflammatory cues activate gene expression in vascular endothelial cells. His trainees have designed and engineered devices to subject a monolayer of cultured endothelial cells to well-defined mechanical forces. He collaborates with Drs. Brown, Chen and Wang.

Pediatrics

Gabriel Haddad, MD  studies the effects of hypoxia and hypercapnia on cell function and development with the goal of improving children’s health. His trainees study mechanisms in hypoxia that lead to cellular injury or protect against it, focusing on human genetic evolution at high altitude, especially in relation to erythropoiesis. He has collaborated with Drs. Malhotra, McCulloch and Cabrales.

Pharmacology

Joan Heller Brown, PhD  works on understanding the mechanisms by which heart failure develops following a myocardial infarction or in response to hypertension. Her current work focuses on the discovery that cardiomyocytes signal through CaMKII to initiate inflammatory activation, macrophage recruitment and fibrosis. Her trainees are testing whether genetic or pharmacologic blockade of these processes attenuates heart failure. She has collaborated with Drs. Chen and Gustafsson.

Jin Zhang, PhD (Pharmacology, Bioengineering, & Chemistry & Biochemistry) works on understanding how cells sense changing environments. Her trainees use FRET sensors, computational models, biochemistry and live cell imaging to reconstruct the dynamic spatiotemporal regulation of protein kinase signaling networks in cardiac and other cells. She has co-mentored trainees with Drs. Wang, McCulloch and Brown.

Radiology

Albert Hsiao, MD, PhD  a radiologist and bioengineer, works on enhancing MRI & CT image acquisition and diagnosis using technologies including 4D Flow MRI and deep learning. His research focuses on structural heart disease, chronic thromboembolic pulmonary hypertension, chronic obstructive pulmonary disease and Covid-19. He collaborates with Drs. Contijoch, McVeigh, Reeves, McCulloch and Engler.

Skaggs School of Pharmacy and Pharmaceutical Sciences

Asa Gustafsson, PhD  works on the molecular pathways that regulate the life and death of cardiac myocytes and their roles in heart disease. Her trainees use systems biology to study the genetic, molecular and physiological interactions of various pathways in heart disease regulating mitochondrial function and apoptosis. She collaborates with Dr. Heller Brown.

 

PROGRAM ADMINISTRATION

PROGRAM DIRECTORS

 

Andrew McCulloch, PhD - Dr. Andrew McCulloch is the Shu Chien Chancellor’s Endowed Chair in Engineering and Medicine at the University of California San Diego and Director of the Institute for Engineering in Medicine. He earned his bachelor (1981) and Ph.D. (1986) degrees in Engineering Science at the University of Auckland and joined the UC San Diego faculty in 1987. He directs the UCSD Interfaces Graduate Training Program and the Interdisciplinary Ph.D. Specialization in Multi-Scale Biology. Dr. McCulloch served as Vice Chair of the Bioengineering Department from 2002 to 2005 and Chair from 2005 to 2008. He is also a member of Qualcomm Institute, a Senior Fellow of the San Diego Supercomputer Center, and Leader of the Wu-Tsai Human Performance Alliance at UC San Diego. 

Karen Christman, PhD - Dr. Karen Christman's has been with the department since 2007. Her research on biomaterials for cardiovascular regenerative medicine has resulted in the development of novel hydrogels derived from extracellular matrices that promote healing after injury. Recently, she successfully conducted a first-in-human, FDA-approved Phase 1 clinical trial of a hydrogel for post-MI tissue repair. She is a member of the IEM and the Sanford Consortium for Regenerative Medicine, and a fellow of the AHA, BMES, and AIMBE. She received NIH Director’s New Innovator and Transformative Research Awards, the Wallace H. Coulter Foundation Early Career Translational Research Award, the AHA Western States Innovative Sciences Award, and the Tissue Engineering and Regenerative Medicine Society’s Young Investigator and Senior Scientist Awards. She currently serves as the Associate Dean for Faculty in the Jacobs School of Engineering. Dr. McCulloch has served as her formal faculty mentor since she was recruited. He will help prepare her transition to serve as the next lead Program Director. She will also take advantage of the National Center for Leadership in Academic Medicine. 

Geert W. Schmid-Schönbein, PhD - Dr. Schmid-Schönbein has been on the Bioengineering faculty since 1979, and is Distinguished Professor and past department chair. He is a past President of the Biomedical Engineering Society, the Microcirculatory Society, and North American Society for Biorheology and past chair of the US National Committee for Biomechanics. He served on or chaired NIH Study Sections on Renal, Cardiovascular, Microcirculation and Hypertension, Systems Biology and Lymphatics Biology. His awards include the Kurt Wiederhielm Award, the Landis Award of the Microcirculatory Society, Fellowships and Honorary Professorships. He was elected to the National Academy of Engineering (NAE) in 2005 and has trained 20 PhD students in microcirculation, lymphatics, cellular and molecular biomechanics, transport modeling and mechanotransduction applied to inflammation, diabetes, hypertension, shock and sepsis. His new treatment for autodigestion is currently in clinical trials.

 

PROGRAM CONTACT

 

Kelley Raymond

Training Grants Program Coordinator
Email: kjraymond@eng.ucsd.edu