Ayako Makino
Associate Professor
Division of Endocrinology and Metabolism
Department of Medicine
University of California, San Diego
Seminar Information
Coronary Microvascular Disease (CMD) is one of the leading causes of mortality and morbidity in Diabetes. The mechanisms responsible for the development of CMD include microvascular rarefaction, small vascular remodeling, and attenuated vasodilatation in coronary small arteries. Coronary vascular endothelial injury and dysfunction are the trigger of CMD; however, the detailed sequence of events remain unclear. In my presentation, I will talk about the pathophysiological role of protein O-GlcNAcylation in the development of CMD in Type 1 and Type 2 diabetic mice.
Dr. Ayako Makino is an Associate Professor in the Division of Endocrinology and Metabolism, Department of Medicine at the University of California, San Diego. She received her Ph.D. in 2000 from the Hoshi University School of Pharmacy and Pharmaceutical Sciences at Tokyo (Japan). Shortly after her graduation, she moved to U.S.A. to complete her postdoctoral training at the Medical College of Wisconsin (Dept. Physiology) and the University of California, San Diego (Dept. Bioengineering). In 2005, she moved to the Department of Medicine as an Assistant Research Scientist and became an Adjunct Assistant Professor in 2009. In 2010, she relocated to the University of Illinois at Chicago as an Assistant Professor. During this period, she developed her own research expertise in coronary micro- and macrovascular dysfunction in diabetes. She moved to the University of Arizona as a tenured Associate Professor in 2014 and came back to the University of California, San Diego as an Associate Professor in Residence in 2019. Dr. Makino has received several honors and awards from national scientific associations and the universities including the Young Investigator Award from The American Physiological Society and Kuriyama Award from Japanese Society of Smooth Muscle Research. She serves as an Ad Hoc and standing reviewer in several study sections and advisory panels of the NIH, AHA, and DOD in the US and the Medical Research Council in UK. Her research is continuously supported by the NIH and she has published 57 research articles and 9 review articles in the field of cardiovascular complication in diabetes and pulmonary hypertension.