News Archive
November 18, 2013
New Models Predict Where E. coli Strains Will Thrive
Bioengineers at the University of California, San Diego have used the genomic sequences of 55 E. coli strains to reconstruct the metabolic repertoire for each strain. Surprisingly, these reconstructions do an excellent job of predicting the kind of environment where each strain will thrive, the researchers found. Their analysis, published in the Nov. 18, 2013 early edition of the Proceedings of the National Academy of Sciences, could prove useful in developing ways to control deadly E. coli infections and to learn more about how certain strains of the bacteria become virulent. Full Story
November 12, 2013
Single-Cell Genome Sequencing Gets Better
Researchers led by bioengineers at the University of California, San Diego have generated the most complete genome sequences from single E. coli cells and individual neurons from the human brain. The breakthrough comes from a new single-cell genome sequencing technique that confines genome amplification to fluid-filled wells with a volume of just 12 nanoliters. Full Story
October 30, 2013
Genomatica Among 100 Companies Highlighted for Economic Boost of Research
Two innovative UC San Diego spinoffs are among the 100 companies cited by The Science Coalition in a new report touting the positive economic payoff of federally funded university research. Genomatica, a biotechnology company that grew from research conducted in Bernhard Palsson’s laboratory at UC San Diego; and Senomyx, a provider of flavor ingredients for the food and beverage industries that arose from research conducted by Charles Zuker at UC San Diego, help demonstrate how support of basic and applied research at American universities pays strong economic dividends. Full Story
October 22, 2013
Bioinformatics Breakthrough: High Quality Transcriptome from as Few as Fifty Cells
Bioengineers from the University of California, San Diego have created a new method for analyzing RNA transcripts from samples of 50 to 100 cells. The approach could be used to develop inexpensive and rapid methods for diagnosing cancers at early stages, as well as better tools for forensics, drug discovery and developmental biology. Full Story
October 17, 2013
Bioengineers Team with High School Students to Study Age-Related Heart Disease
Bioengineering professor Adam Engler recently launched a six-week fruit fly experiment with a group of 11th grade biology students in a study of age-related heart disease. The question driving the project is whether genetic mutations in the heart, mutations that are common in humans as we age and that are correlated with poor heart function, also contribute to a shortened lifespan? Full Story
October 8, 2013
Bioengineers uncover cause, treatment for insulin resistance in shock patients
Bioengineers at the University of California, San Diego have discovered that insulin resistance in shock patients is caused by the leakage of powerful digestive enzymes from the small intestine that eat away and destroy the insulin receptor in cells. Reporting in the journal Shock, the team has also found a way to stop these enzymes’ destructive path by blocking them in the intestine, where they are normally used to digest food. The research team includes Frank DeLano, lead investigator, and co-investigator Geert Schmid-Schönbein, professor and chair of bioengineering at UC San Diego Jacobs School of Engineering. Doctors have long known that trauma patients going into shock are at risk of developing acute insulin resistance, leading to hyperglycemia. The pancreas releases insulin to deliver glucose to cells to convert into energy for the body. When cells are unable to process insulin properly, a condition known as insulin resistance, blood sugars rise and the pancreas releases more insulin, compounding the problem. Until now, doctors have not known what mechanism causes insulin resistance to develop in shock patients or how to treat it. Full Story
October 1, 2013
Computer Scientists Develop New Approach to Sort Cells Up to 38 Times Faster
A team of engineers led by computer scientists at the University of California, San Diego, has developed a new approach that marries computer vision and hardware optimization to sort cells up to 38 times faster than is currently possible. The approach could be used for clinical diagnostics, stem cell characterization and other applications. Full Story
September 18, 2013
'Wildly Heterogeneous Genes'
Cancer tumors almost never share the exact same genetic mutations, a fact that has confounded scientific efforts to better categorize cancer types and develop more targeted, effective treatments. In a paper published in the September 15 advanced online edition of Nature Methods, researchers at the University of California, San Diego propose a new approach called network-based stratification (NBS), which identifies cancer subtypes not by the singular mutations of individual patients, but by how those mutations affect shared genetic networks or systems. Full Story
September 17, 2013
Bioengineers Researching Smart Cameras and Sensors that Mimic, Exceed Human Capability
University of California, San Diego bioengineering professor Gert Cauwenberghs has been selected by the National Science Foundation to take part in a five-year, multi-institutional, $10 million research project to develop a computer vision system that will approach or exceed the capabilities and efficiencies of human vision. Full Story
September 4, 2013
UC San Diego Bioengineering and IEM Programmer Named 2013 Presidential Innovation Fellow
Justin Grevich, a web developer and systems administrator in bioengineering and the Institute of Engineering in Medicine, has been named a 2013 Presidential Innovation Fellow. Full Story
August 12, 2013
New electron beam writer enables next-gen biomedical and information technologies
The new electron beam writer housed in the Nano3 cleanroom facility at the Qualcomm Institute is important for electrical engineering professor Shadi Dayeh’s two major areas of research. He is developing next-generation, nanoscale transistors for integrated electronics; and he is developing neural probes that have the capacity to extract electrical signals from individual brain cells and transmit the information to a prosthetic device or computer. Achieving this level of signal extraction or manipulation requires tiny sensors spaced very closely together for the highest resolution and signal acquisition. Enter the new electron beam writer. Full Story
July 29, 2013
Conference for African-American Researchers in Mathematics Connects Students to Mentors
For Lauren Crudup, a third-year bioengineering student at the University of California, San Diego, the Conference for African-American Researchers in the Mathematical Sciences (CAARMS) presented a unique opportunity to learn just how applicable mathematics is in the real-world—especially compared to the pure mathematics she learned in high school and earlier undergraduate courses. Full Story
June 27, 2013
Faculty Invited to Exclusive Symposium for 'Creative Young Engineers'
Jacobs School of Engineering professors Karen Christman and Gert Lanckriet are among 81 of the nation’s most “creative young engineers” selected to attend this year’s U.S. Frontiers of Engineering Symposium by the National Academy of Engineering. Participation in the event is by invitation-only to engineers between the ages of 30-45 who have “demonstrated accomplishment in engineering research and technical work with recognizable contributions to advancing the frontiers of engineering,” according to an NAE announcement. Full Story
June 21, 2013
Technology-Enhanced Learning: From Campus to the World
The academic landscape is changing rapidly, due in no small part to recent advances in technologies to enable, enhance and deliver teaching and learning to a worldwide audience. At the University of California, San Diego, administrators and faculty are particularly focused on using technology to transform the undergraduate learning experience (saving money in the process). They’re doing this in the context of the UC San Diego Education Initiative, as well as the Technology-Enhanced Learning (TEL) Initiative jump-started by Calit2’s Qualcomm Institute. Both programs are helping to formulate a way forward for the campus, with the Education Initiative focused on policy, and the TEL Initiative experimenting with various models of online learning. Full Story
June 6, 2013
Metabolic Model of E. coli Integrated with Protein Structures Reveals How Bacterial Growth Responds to Temperature Change
Bioengineers at the University of California, San Diego have developed a computational model of 1,366 genes in E. colithat includes 3D protein structures and has enabled them to compute the temperature sensitivity of the bacterium’s proteins. The study, published June 7 in the journal Science, opens the door for engineers to create heat-tolerant microbial strains for production of commodity chemicals, therapeutic proteins and other industrial applications. Full Story
May 31, 2013
Bioengineer Christian Metallo Selected as 2013 Searle Scholar and Hellman Faculty Fellow
University of California, San Diego bioengineering professor Christian Metallo has been named a 2013 Searle Scholar. He will receive $300,000 over the next three years to pursue his research on the role of oxygen availability in dictating how fat is produced and metabolized in the body. This work will provide therapeutic insights into metabolic diseases such as obesity. Metallo is one of just 15 young investigators across the United States selected from 176 applications submitted by 125 universities.Metallo is the first Searle Scholar representing the UC San Diego Jacobs School of Engineering. Full Story
May 16, 2013
UC San Diego Creates Center for Brain Activity Mapping
Responding to President Barack Obama’s “grand challenge” to chart the function of the human brain in unprecedented detail, the University of California, San Diego has established the Center for Brain Activity Mapping (CBAM). The new center, under the aegis of the interdisciplinary Kavli Institute for Brain and Mind at UC San Diego, will tackle the technological and biological challenge of developing a new generation of tools to enable recording of neuronal activity throughout the brain. It will also conduct brain-mapping experiments and analyze the collected data. Full Story
March 11, 2013
Alumnus Mike Chi is Developing Better EEG Recording Equipment at Cognionics
When Mike Chi finished his Ph.D. in Electrical Engineering at UC San Diego in 2011, he co-founded Cognionics. One of his big goals is to put better sensor technologies into the labs of researchers and physicians who study the electrical signals produced by the brain (EEG) and heart (ECG) for a variety of basic research and medical applications such as diagnosing cardiac disorders or conducting high-resolution brain imaging on freely moving subjects. Full Story
March 11, 2013
What is the Story Behind the Research Expo Gold Squares?
The gold squares on the Research Expo 2013 postcards…what are they? The gold squares are ceramic packages that house experimental circuits developed in the lab of bioengineering professor Gert Cauwenberghs at the UC San Diego Jacobs School of Engineering. The research is aimed at developing new circuits that increase the speed and decrease the energy required to wirelessly transfer biological data—such as ECG signals from the heart and EEG signals from the brain—from sensors worn on the body to nearby data collectors. Full Story
March 4, 2013
International Consortium Builds 'Google Map' of Human Metabolism
Building on earlier pioneering work by researchers at the University of California, San Diego, an international consortium of university researchers has produced the most comprehensive virtual reconstruction of human metabolism to date. Scientists could use the model, known as Recon 2, to identify causes of and new treatments for diseases like cancer, diabetes and even psychiatric and neurodegenerative disorders. Full Story